Abstract Search

ea0056gp110 | Diabetes Translational | ECE2018

Knock-down of class 2a histone deacetylases (HDACs) in hepatocytes of healthy mice does not affect gluconeogenesis but is associated with increased hematopoiesis

Bielohuby Maximilian , Raichur Suryaprakash , Stolte Manuela , Hemmann Ulrike , Gorgens Sven W , Wohlfart Paulus , Jahn-Hofmann Kerstin , Brunner Bodo , Tennagels Norbert

Class 2a HDACs (i.e. HDAC 4, 5, 7 and 9) are involved in the regulation of gluconeogenesis and accordingly, their inhibition has been shown to result in lower blood glucose and improved pyruvate tolerance in diabetic mice. However, pan-inhibition of HDACs is not a viable approach for chronic treatment of type 2 diabetes (T2D) due to induction of severe side effects in various tissues. We now have investigated in vitro and in vivo efficacy and safety of a live...

0 shares

Endocrine Abstracts

Knock-down of class 2a histone deacetylases (HDACs) in hepatocytes of healthy mice does not affect gluconeogenesis but is associated with increased hematopoiesis

BiosciAbstracts